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SECOND OPINION CRLClinical Reference Laboratory

Specialist Pathology Review

Pathology Second Opinion

Independent specialist review for diagnostically challenging cases. Histopathology • Cytopathology • IHC • Oncopathology • Ancillary Testing

Why Choose Second Opinion CRL

Built around diagnostic clarity.

  • Specialist Review

    Focused review of diagnostically challenging pathology cases.

  • Independent Assessment

    A fresh evaluation of the available pathology material and clinical information.

  • Integrated IHC & Ancillary Testing

    Additional investigations when clinically appropriate.

  • Structured Reporting

    Clear, clinically relevant diagnostic interpretation.

  • Confidentiality

    Responsible handling of patient and diagnostic information.

What can we review?

Pathology material and diagnostic information can be reviewed according to the requirements of the case and the material available.

Histopathology

  • H&E slides
  • Special stains
  • Paraffin blocks
  • Previous pathology reports

IHC

  • IHC slides
  • IHC reports
  • Unstained slides
  • Tissue blocks for additional IHC, where appropriate

Cytology

  • FNAC smears
  • Cytology slides
  • Cell blocks
  • Fluid cytology

Haematopathology

  • Peripheral blood smears
  • Bone marrow slides
  • Lymph-node material
  • IHC/flow-cytometry reports

Ancillary Investigations

  • FISH
  • PCR
  • Molecular reports
  • NGS reports

Have a challenging pathology case?

Pathology Second Opinion

Independent specialist review for diagnostically challenging cases

Histopathology • Cytopathology • IHC • Oncopathology • Ancillary Testing

A second opinion provides an additional specialist assessment of the available pathology material and clinical information, particularly when the diagnosis is complex, unusual, uncertain or clinically consequential.
  1. 01

    Submit Your Case

    Provide the pathology report, slides/blocks and relevant clinical information.

  2. 02

    Case Assessment

    The available material is assessed to determine the scope of review and whether additional material/testing may be required.

  3. 03

    Specialist Pathology Review

    The case is independently reviewed with correlation of morphology, IHC and relevant clinical information.

  4. 04

    Additional Testing, If Required

    Additional IHC, special stains or ancillary/molecular testing may be recommended when appropriate.

  5. 05

    Final Opinion

    A structured pathology opinion is issued and communicated through the agreed process.

Frequently Asked Questions

Information regarding our specialist pathology review process.

A pathology second opinion is an independent assessment of your pathology material and diagnostic reports by a specialist pathologist. It provides a fresh evaluation to ensure accuracy and clarity for your diagnosis.

A second opinion may be considered for new cancer diagnoses, rare or unusual tumours, difficult or borderline diagnoses, discordant pathology and imaging, unexpected recurrences, or before major cancer treatment.

Pathology material prepared by another laboratory may be considered for review, subject to assessment of the material available and the requirements of the case.

Yes, paraffin blocks can be reviewed and are often preferred as they allow for additional sectioning and ancillary testing if required.

Additional IHC may be recommended when clinically appropriate and will depend on the diagnostic question and available material.

Yes, we review cytology specimens including FNAC smears, fluid cytology, and cell blocks.

Yes, our specialist pathology review covers complex oncopathology cases including lymphoma and sarcoma work-ups.

Yes, the original pathology report, along with relevant clinical information and imaging findings, is essential for a comprehensive review.

Review timelines depend on the complexity of the case, the material available and whether additional assessment or testing is required. The expected process can be discussed when the case is submitted.

The final opinion is communicated through the agreed process for the case.

Yes, we encourage multidisciplinary communication. Your treating doctor can discuss the findings with our specialist pathologist.

A second opinion may confirm the original interpretation or provide a different assessment. Where the interpretations differ, the findings should be discussed in the context of the available clinical, radiological and pathological information, and further review or investigation may be recommended where appropriate.

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